Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (12): 4357-4363.DOI: 10.6023/cjoc202005078 Previous Articles     Next Articles


丁雨昕a,b, 马永敏a,b, 陈静a   

  1. a 浙江中医药大学药学院 浙江杭州 310053;
    b 台州大学医药化工学院 浙江台州 318000
  • 收稿日期:2020-05-28 修回日期:2020-06-28 发布日期:2020-07-23
  • 通讯作者: 马永敏, 陈静;
  • 基金资助:

Novel Three-Component Annulation for the Synthesis of 2,4,6-Triaryl-pyrimidines under Solvent-Free and Catalyst-Free Conditions

Ding Yuxina,b, Ma Yongmina,b, Chen Jinga   

  1. a School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053;
    b School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, Zhejiang 318000
  • Received:2020-05-28 Revised:2020-06-28 Published:2020-07-23
  • Supported by:
    Project supported by the Natural Science Foundation of Zhejiang Province (No. LY19H300001), the Zhejiang Chinese Medicinal University Foundation (No. 2018ZG31) and the "Teacher Professional Development Project" for Domestic Visitors of Institutions of Higher Learning in 2019 (No. FX2019020).

2,4,6-Triarylpyrimidines were synthesized via a simple, efficient, one-pot, three-component reaction from 1,3-dikeones, benzaldehydes and ammonium acetate under solvent-free and catalyst-free conditions in good to excellent yields. This "green" methodology provides an eco-friendly protocol for the construction of the pyrimidine framework.

Key words: catalyst-free, solvent-free, one-pot, three-component reaction, 2,4,6-triarylpyrimidine