Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (1): 111-136.DOI: 10.6023/cjoc202307016 Previous Articles     Next Articles

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无过渡金属或无光催化剂条件下可见光促进喹喔啉酮C(3)—H官能团化研究进展

董江湖a, 宣良明a, 王池a, 赵晨熙a, 王海峰a, 严琼姣a,*(), 汪伟a,*(), 陈芬儿a,b,*()   

  1. a 武汉工程大学药物研究院 武汉 430205
    b 复旦大学化学系 上海 200433
  • 收稿日期:2023-07-16 修回日期:2023-08-25 发布日期:2023-09-21
  • 作者简介:
    共同第一作者.
  • 基金资助:
    Scientific Research Project of Education Department of Hubei Province(Q20211503)

Recent Advances in Visible-Light-Induced C(3)—H Functionalization of Quinoxalinones under Transition-Metal-Free or Photocatalyst-Free

Jianghu Donga, Liangming Xuana, Chi Wanga, Chenxi Zhaoa, Haifeng Wanga, Qiongjiao Yana(), Wei Wanga(), Fen'er Chena,b()   

  1. a Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan 430205
    b Department of Chemistry, Fudan University, Shanghai 200433
  • Received:2023-07-16 Revised:2023-08-25 Published:2023-09-21
  • Contact: *E-mail: 875531154@qq.com; E-mail: wang520520wei@163.com; E-mail: rfchen@fudan.edu.cn
  • About author:
    These authors contributed equally to this work.

Quinoxalinone and its derivatives are significant non-aromatic heterocycles existing in various bioactive natural products, pharmaceuticals, and functional materials, and exhibit an impressive spectrum of important biological properties. In recent years, the functionalization of quinoxalinones has attracted extensive attention of chemical workers, and important progress has made in the construction of C-3 substituted quinoxalinones by C—H functionalization. Photoredox catalysis has been widely used in the synthesis and conversions of organic compounds, because it can generate high reactive free radical intermediates under mild conditions using green and clean energy. Thus, photocatalysis synthesis is becoming powerful tools for C—H functionalization of quinoxalinone. This photocatalytic reactions under transition-metal-free or photocatalyst-free conditions meet the requirements of green chemistry and sustainable development, which have become a powerful tool for the functionalization of quinoxalinones and attracted the attention of many scholars. The research progress of C(3)—H functionalization of quinoxalinones by visible-light photoredox catalysis under transition-metal-free or photocatalyst-free conditions is reviewed during the past five years. The reaction mechanisms are systematically discussed, and the challenges and opportunities of this field are included.

Key words: quinoxalinone, photoredox, transition-metal-free, photocatalyst-free, C—H functionalization