Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (12): 4323-4331.DOI: 10.6023/cjoc202208036 Previous Articles     Next Articles

Special Issue: 自由基化学专辑



巫晓婷a, 赵峰b,*(), 姬小趁a, 黄华文a,c,*()   

  1. a 湘潭大学化学学院 湖南湘潭 411105
    b 湖南医药学院药学院 湖南怀化 418000
    c 河南师范大学化学化工学院 河南新乡 453007
  • 收稿日期:2022-08-25 修回日期:2022-09-24 发布日期:2022-10-14
  • 通讯作者: 赵峰, 黄华文
  • 基金资助:
    国家自然科学基金(22071211); 国家自然科学基金(21801076); 河南师范大学化学化工学院开放基金(2022C02)

Visible Light-Assisted Photocatalyst-Free Tandem Sulfonylation/ Cyclization for the Synthesis of Oxindoles

Xiaoting Wua, Feng Zhaob(), Xiaochen Jia, Huawen Huanga,c()   

  1. a College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105
    b School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, Hunan 418000
    c School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007
  • Received:2022-08-25 Revised:2022-09-24 Published:2022-10-14
  • Contact: Feng Zhao, Huawen Huang
  • Supported by:
    National Natural Science Foundation of China(22071211); National Natural Science Foundation of China(21801076); Open Research Fund of School of Chemistry and Chemical Engineering of Henan Normal University(2022C02)

Oxindole derivatives are well developed in many fields, and this special heterocyclic scaffold is more and more widely used in natural products and bioactive molecules due to its unique functionality. Therefore, it is very important to explore new synthesis methods for this motif. A visible light-assisted photocatalyst-free protocol for the efficient synthesis of sulfonylated oxindoles under mild condition was reported. The present method starts from simple and readily available N-arylacrylamide and sodium sulfinates, uses cheap K2S2O8 as oxidant, and features moderate to good yields and excellent functional group tolerance.

Key words: photocatalysis, N-arylacrylamide, oxindole, cyclization, photocatalyst-free