Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (10): 3132-3153.DOI: 10.6023/cjoc202005092 Previous Articles     Next Articles

1,3-偶极子[3+n](n≥3)环加成反应的研究进展

乐贵洲a, 刘波b   

  1. a 四川农业大学理学院 四川雅安 625014;
    b 四川大学化学学院 绿色化学与技术教育部重点实验室 成都 610064
  • 收稿日期:2020-05-30 修回日期:2020-06-19 发布日期:2020-07-01
  • 通讯作者: 乐贵洲 E-mail:yueguizhou@sicau.edu.cn;chembliu@scu.edu.cn
  • 基金资助:
    四川省科技计划(No.2020YFH0129)资助项目.

Research Progress on [3+n] (n≥3) Cycloaddition of 1,3-Diploes

Yue Guizhoua, Liu Bob   

  1. a School of Science, Sichuan Agricultural University, Ya'an, Sichuan 625014;
    b Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064
  • Received:2020-05-30 Revised:2020-06-19 Published:2020-07-01
  • Supported by:
    Project supported by the Science and Technology Program of Sichuan Province (No. 2020YFH0129).

Versatile heterocyclic skeletons extensively exist in structures of natural products, drug molecules and organic materials, and have been synthesized through various strategies reported in literatures. Among them, the 1,3-dipolar cycloaddition is the most impressive class to build the related heterocycles. In the past, organic chemists generally employed[3+2] cycloaddition of 1,3-dipoles to assemble five-membered rings. As modern chemistry developes, researchers further turn their attention to the[3+3],[3+4],[3+5] and[3+6] cycloadditions, to construct six-, seven-, eight- and bridge-heterocyclic compounds. At present, review articles with topics on 1,3-dipolar cycloaddition mainly focus on[3+2] cycloaddition. Herein, A topic on[3+n] (n ≥ 3) cycloaddition of 1,3-dipoles, with comments on the developed methodologies is present and the outlook in this field is proposed.

Key words: 1,3-diploar cycloaddtion, nitrone, azomethine ylide, azomethine imine, nitrile imine, nitrile oxide, nitrile ylide