Progress in Structural Modification of Bicyclic Thiopeptide Antibiotics Based on Biosynthesis

doi:10.6023/cjoc202005071

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (10): 3120-3131.DOI: 10.6023/cjoc202005071 Previous Articles Next Articles

Special Issue: 黄乃正院士七十华诞专辑

基于生物合成的双环硫肽类抗生素结构改造进展

张鄂^a, 陈单丹^b, 王守锋^a, 刘文^b,c

a 济南大学化学化工学院山东省氟化学化工材料重点实验室济南 250022;
b 中国科学院上海有机化学研究所生命有机化学国家重点实验室上海 200032;
c 中国科学院上海有机化学研究所湖州生物制造中心浙江湖州 313000

收稿日期:2020-05-26 修回日期:2020-06-20 发布日期:2020-07-09
通讯作者: 王守锋, 刘文 E-mail:chm_wangsf@ujn.edu.cn;wliu@mail.sioc.ac.cn
基金资助:
国家自然科学基金（Nos.31972850，21750004，21520102004）、山东省重点研发计划（No.2019GSF108223）、中国科学院（Nos.QYZDJ-SSW-SLH037，XDB20020200）、上海市科委（No.17JC1405100）、中国科学院青年创新促进会（No.2017303）和王宽诚教育基金会资助项目.

Progress in Structural Modification of Bicyclic Thiopeptide Antibiotics Based on Biosynthesis

Zhang E^a, Chen Dandan^b, Wang Shoufeng^a, Liu Wen^b,c

a Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022;
b State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
c Huzhou Center of Bio-Synthetic Innovation, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Huzhou, Zhejiang 313000

Received:2020-05-26 Revised:2020-06-20 Published:2020-07-09
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 31972850, 21750004, 21520102004), the Shandong Key Research Program (No. 2019GSF108223), the Chinese Academy of Sciences (Nos. QYZDJ-SSW-SLH037, XDB20020200), the Science and Technology Commission of Shanghai Municipality (No. 17JC1405100), the Youth Innovation Promotion Association of the Chinese Academy of Sciences (No. 2017303), and the K. C. Wong Education Foundation.

Thiopeptide antibiotics are a class of natural products with polythiophene (oxazol) polypeptides, which are rich in sulfur and highly modified. They are produced by secondary metabolism of microorganisms and have good biological activities. Developing thiopeptides into clinic is currently a challenge partly due to their low aqueous solubility and associated poor bioavailability. On the basis of understanding the mechanism of their biosynthesis, the method of obtaining thiopeptide analogues via reasonable bioengineering has become the research focus of biologists. In this paper, the advances in structural modifications of bicyclic thiopeptides by taking thiostrepton and nosiheptide as representatives are reviewed.

Key words: biosynthesis, thiostrepton, nosiheptide, structural modifications

Cite this article

Zhang E, Chen Dandan, Wang Shoufeng, Liu Wen. Progress in Structural Modification of Bicyclic Thiopeptide Antibiotics Based on Biosynthesis[J]. Chinese Journal of Organic Chemistry, 2020, 40(10): 3120-3131.

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基于生物合成的双环硫肽类抗生素结构改造进展

Progress in Structural Modification of Bicyclic Thiopeptide Antibiotics Based on Biosynthesis

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