Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (1): 325-332.DOI: 10.6023/cjoc202006029 Previous Articles     Next Articles



胡智宇a, 姜国芳a,*(), 祝志强a, 龚伯桢a, 谢宗波a, 乐长高a,*()   

  1. a 东华理工大学 江西省合成化学重点实验室 江西南昌 330013
  • 收稿日期:2020-06-15 修回日期:2020-07-16 发布日期:2020-08-27
  • 通讯作者: 姜国芳, 乐长高
  • 作者简介:
    * Corresponding authors. E-mail: ;
  • 基金资助:
    国家自然科学基金(11765002); 江西省科技计划(20192BBH80012)

One-Pot Domino Henry-Friedel-Crafts Alkylation Reaction in Deep Eutectic Solvent

Zhiyu Hua, Guofang Jianga,*(), Zhiqiang Zhua, Bozhen Gonga, Zongbo Xiea, Zhanggao Lea,*()   

  1. a Jiangxi Province Key Laboratory of Synthetic Chemistry, East China University of Technology, Nanchang, Jiangxi 330013
  • Received:2020-06-15 Revised:2020-07-16 Published:2020-08-27
  • Contact: Guofang Jiang, Zhanggao Le
  • Supported by:
    the National Natural Science Foundation of China(11765002); the Science and Technology Projects of Jiangxi Province(20192BBH80012)

A green multicomponent reaction between aldehydes, nitromethane and N-substituted anilines in deep eutectic solvent (DES) has been developed. In this reaction, aldehydes and nitromethane underwent Henry reaction, followed by a Friedel-Crafts alkylation reaction with electron-rich arenes. The desired products were formed quickly in excellent yields under mild conditions without the need of any additional catalysts. The deep eutectic solvent (zinc chloride and choline chloride) is cheap and recyclable, which reduces the synthesis cost.

Key words: deep eutectic solvent, Henry reaction, Friedel-Crafts reaction, one pot reaction, tandem reaction