Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (2): 567-581.DOI: 10.6023/cjoc202006060 Previous Articles     Next Articles



王李娟b, 盛显良a, 王杰a, 张玉辉a,*()   

  1. a 内蒙古农业大学理学院 呼和浩特 010018
    b 内蒙古农业大学材料科学与艺术设计学院 呼和浩特 010018
  • 收稿日期:2020-06-28 修回日期:2020-08-04 发布日期:2020-09-16
  • 通讯作者: 张玉辉
  • 作者简介:
    * Corresponding author. E-mail:
  • 基金资助:
    内蒙古自治区高等学校“青年科技英才支持计划”(NJYT-19-B26); 内蒙古自治区自然科学基金博士基金(2017BS0206); 及内蒙古农业大学高层次人才引进科研启动(NDGCC2016-21)

Application of Boronate Bond in Drug Delivery System

Lijuan Wangb, Xianliang Shenga, Jie Wanga, Yuhui Zhanga,*()   

  1. a College of Science, Inner Mongolia Agricultural University, Hohhot 010018
    a College of Material Science and Art Design, Inner Mongolia Agricultural University, Hohhot 010018
  • Received:2020-06-28 Revised:2020-08-04 Published:2020-09-16
  • Contact: Yuhui Zhang
  • Supported by:
    the Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(NJYT-19-B26); the Doctor Fund of Inner Mongolia Autonomous Region Natural Science Fund(2017BS0206); the Program of Higher-level Talents Introduction and Scientific Research Start of Inner Mongolia Agricultural University(NDGCC2016-21)

Because of its excellent controlled release properties, stimulus-responsive drug carriers have attracted extensive attention in the field of biomedicine and have achieved extremely rapid development. Boronate bonds have been widely used as a stimulus-responsive site in the construction of drug carriers because of its simple construction conditions, good biocompatibility, and fast responsiveness to various micro-environmental changes such as pH, glucose and 5'-adenosine triphosphate (ATP) concentration in vivo. The types of drug carriers based on boronate bonds include drug-polymer conjugate, polymer micelles, linear-hyperbranched polymers and mesoporous silica, which could load anticancer drugs and deliver insulin and genes. Besides, drugs could be integrated into carrier by covalent bonding, physical encapsulation, and electrostatic interactions, which could be released at specific sites via endogenous stimuli. The application of boronate bond in drug delivery system is reviewed from four aspects: drug types, carrier types, combination mode of drug and carrier as well as breaking mechanism of boronate bond. The main challenges and future advances in this field are also detailed.

Key words: stimulus-responsive, drug carrier, boronate bond