Synthesis of PPEGMEA-g-PBLG Amphiphilic Graft Copolymer and Its Research as Doxorubicin Delivery Vectors

doi:10.6023/cjoc201310043

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (12): 2520-2527.DOI: 10.6023/cjoc201310043 Previous Articles Next Articles

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PPEGMEA-g-PBLG两亲性接枝共聚物的合成及其作为阿霉素输送载体的研究

蔡晓冰^a, 胡薇^b, 陆国林^c, 黄晓宇^c

a 同济大学附属上海第十人民医院骨科上海 200072;
b 第二军医大学附属长海医院普四科上海 200433;
c 中国科学院上海有机化学研究所上海 200032

收稿日期:2013-10-26 修回日期:2013-11-11 发布日期:2013-11-14
通讯作者: 胡薇，黄晓宇 E-mail:huweicj@163.com；xyhuang@mail.sioc.ac.cn
基金资助:
国家自然科学基金(Nos. 81171737，21174158)资助项目.

Synthesis of PPEGMEA-g-PBLG Amphiphilic Graft Copolymer and Its Research as Doxorubicin Delivery Vectors

Cai Xiaobing^a, Hu Wei^b, Lu Guolin^c, Huang Xiaoyu^c

a Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072;
b Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433;
c Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received:2013-10-26 Revised:2013-11-11 Published:2013-11-14
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 81171737, 21174158).

The poly[poly(ethylene glycol) methyl ether acrylate] (PPEGMEA) backbone was first prepared by single electron transfer-living radical polymerization (SET-LRP). The backbone was treated with lithium diisopropylamide (LDA) and 2-bromoisobutyryl bromide at －78 ℃ to give Br-containing PPEGMEA-Br. PPEGMEA-NH₂ macroinitiator was then prepared by successive substitution and reduction reactions. A series of well-defined PPEGMEA-g-PBLG graft copolymers were synthesized by ring-opening graft polymerization of γ-benzyl-L-glutamate-N-carboxyanhydride (BLG-NCA) via grafting-from technique. A series of doxorubicin (DOX)-loaded polymeric micelles based on PPEGMEA-g-PBLG amphiphilic graft copolymers were prepared. The drug loading content (DLC) was measured by UV and the DLC of polymeric micelles was found to be as high as 32.3%. The drug release in vitro showed good delayed drug release feature.

Key words: amphiphilic graft copolymer, single electron transfer-living radical polymerization, doxorubicin, drug carrier

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Cai Xiaobing, Hu Wei, Lu Guolin, Huang Xiaoyu. Synthesis of PPEGMEA-g-PBLG Amphiphilic Graft Copolymer and Its Research as Doxorubicin Delivery Vectors[J]. Chin. J. Org. Chem., 2013, 33(12): 2520-2527.

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PPEGMEA-g-PBLG两亲性接枝共聚物的合成及其作为阿霉素输送载体的研究

Synthesis of PPEGMEA-g-PBLG Amphiphilic Graft Copolymer and Its Research as Doxorubicin Delivery Vectors

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