Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (4): 1734-1738.DOI: 10.6023/cjoc202010014 Previous Articles     Next Articles



张玲玲a,*(), 王知b, 吴剑a, 李小青b,*()   

  1. a 江苏环保产业技术研究院股份公司 南京 210019
    b 浙江工业大学化学工程学院 杭州 310014
  • 收稿日期:2020-10-11 修回日期:2020-11-13 发布日期:2020-12-05
  • 通讯作者: 张玲玲, 李小青

Synthesis of Nitro-Functionalized Isoquinolinediones via NaNO2/Na2S2O8-Mediated Arylnitration of Alkenes

Lingling Zhanga,*(), Zhi Wangb, Jian Wua, Xiaoqing Lib,*()   

  1. a Jiangsu Academy of Environmental Industry and Technology Corp., Nanjing 210019
    b College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2020-10-11 Revised:2020-11-13 Published:2020-12-05
  • Contact: Lingling Zhang, Xiaoqing Li
  • About author:
    * Corresponding authors. E-mail: ;

A new method for the synthesis of nitro-functionalized isoquinolinediones by arylnitration of methacryloylbenzamides has been reported. Readily accessible NaNO2/Na2S2O8 was used as nitro radical precursor, and 18-crown-6 was used to promote the reaction. Compared with the existing method, this method is not only environmentally friendly but also easy to operate.

Key words: Keywords alkenes, arylnitration, cyclization, nitro radical, isoquinolinediones