Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (3): 1115-1123.DOI: 10.6023/cjoc202210033 Previous Articles     Next Articles

Special Issue: 有机氟化学虚拟合辑 中国女科学家专辑



曾成富a, 何媛b, 李清a,*(), 董琳b,*()   

  1. a 四川师范大学化学与材料科学学院 成都 610066
    b 四川大学华西药学院 成都 610041
  • 收稿日期:2022-10-27 修回日期:2022-12-30 发布日期:2023-02-06
  • 通讯作者: 李清, 董琳
  • 基金资助:
    四川省科技计划(2021YFG0111); 国家自然科学基金(22107082); 四川省中央引导地方科技发展专项(2021ZYD0058)

Ir(III)-Catalyzed Novel Three-Component Cascade Trifluoroethoxylation and One-Pot Method to Construct Complex Amide Compounds

Chengfu Zenga, Yuan Heb, Qing Lia(), Lin Dongb()   

  1. a College of Chemistry and Material Science, Sichuan Normal University, Chengdu 610066
    b West China School of Pharmacy, Sichuan University, Chengdu 610041
  • Received:2022-10-27 Revised:2022-12-30 Published:2023-02-06
  • Contact: Qing Li, Lin Dong
  • Supported by:
    Sichuan Science and Technology Program(2021YFG0111); National Natural Science Foundation of China(22107082); Sichuan Science and Technology Development under the Central Government(2021ZYD0058)

Ir(III)-catalyzed three-component cascade reaction to construct unique trifluoroethoxylation amide compounds has been developed, meanwhile the fluorinated compounds could continue to react with alcohols to prepare complex spiro isoindolinone derivatives in one-pot. The highly efficient approaches produce various amide compounds by condition- controlled.

Key words: three-component cascade reaction, fluorination, spirocyclization, 2-aryloxazole