Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (5): 1878-1887.DOI: 10.6023/cjoc202010026 Previous Articles     Next Articles



张馨元1, 林礼1, 李静1, 段世妤1, 隆宇航1, 李加洪1,*()   

  1. 1 西南交通大学生命科学与工程学院 成都 610031
  • 收稿日期:2020-10-18 修回日期:2020-11-30 发布日期:2020-12-10
  • 通讯作者: 李加洪
  • 基金资助:

Recent Progress in the Synthesis of Medium-Sized Ring and Macrocyclic Compounds

Xinyuan Zhang1, Li Lin1, Jing Li1, Shiyu Duan1, Yuhang Long1, Jiahong Li1,*()   

  1. 1 School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
  • Received:2020-10-18 Revised:2020-11-30 Published:2020-12-10
  • Contact: Jiahong Li
  • About author:
    * Corresponding author. E-mail:
  • Supported by:
    Student's Platform for Innovation and Entrepreneurship Training Program(201910613081)

Medium-sized rings (8~11 membered ring) and macrocycles (12-membered rings and above) are extremely important parts of drug and natural products. Meanwhile, they are widely used in the field of medicinal chemistry, organic chemistry and other fields. Developing simple, green and efficient protocol to synthesize medium-sized rings and macrocycles has attracted great interests from chemists in the recent years. The latest ring expansion/cyclization reaction in the synthesis of medium-sized ring and macrocyclic compounds in the past five years is reviewed, and the prospect of their future and development is also outlined.

Key words: medium-sized ring, macrocycle, ring expansion reaction, cyclization