Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (6): 2249-2260.DOI: 10.6023/cjoc202012008 Previous Articles     Next Articles



吕润秋, 张维, 于丽芳*()   

  1. 华东师范大学化学与分子工程学院 上海分子治疗与新药创制工程技术研究中心 上海 200062
  • 收稿日期:2020-12-04 修回日期:2021-01-21 发布日期:2021-02-22
  • 通讯作者: 于丽芳
  • 基金资助:

Recent Advances in Antitubercular Compounds Targeting Mycolic Acid Biosynthesis and Transport

Runqiu Lü, Wei Zhang, Lifang Yu()   

  1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062
  • Received:2020-12-04 Revised:2021-01-21 Published:2021-02-22
  • Contact: Lifang Yu
  • Supported by:
    National Natural Science Foundation of China(21778019)

Tuberculosis is now recognized as the most fatal infectious disease worldwide, eclipsing HIV in recent years. Drug-resistance tuberculosis continues to be a severe public crisis. The cure rate in persons with multidrug-resistant tuberculosis (MDR-TB) is unacceptably low, and the treatment of MDR-TB requires complex treatment regimens over a long period. There is a great opportunity in the field of tuberculosis as novel chemical entities with different mechanisms of action are particularly needed. The biosynthesis and transport pathways of mycolic acid represents a well proven and effective target for chemical intervention for TB. This article reviews the important inhibitors targeting to this pathway, as well as the recent research advances in the mechanism and pharmacokinetic properties etc.

Key words: drug-resistant tuberculosis, biosynthesis and transport pathway of mycolic acid, important targets, inhibitors