Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (8): 3073-3082.DOI: 10.6023/cjoc202104059 Previous Articles     Next Articles

ARTICLES

钯催化串联Heck环化反应制备氮杂桥环化合物

李曼, 汪颖, 徐允河*()   

  1. 中国科学技术大学化学与材料科学学院 合肥 230026
  • 收稿日期:2021-04-29 修回日期:2021-05-11 发布日期:2021-05-25
  • 通讯作者: 徐允河
  • 基金资助:
    国家自然科学基金(21871240); 中央高校基本科研业务费专项资金(WK2060000017)

Palladium-Catalyzed Tandem Heck Cyclization Reactions to Access the Bridged N-Heterocyclic Compounds

Man Li, Ying Wang, Yunhe Xu()   

  1. Department of Chemistry, University of Science and Technology of China, Hefei 230026
  • Received:2021-04-29 Revised:2021-05-11 Published:2021-05-25
  • Contact: Yunhe Xu
  • Supported by:
    National Natural Science Foundation of China(21871240); Fundamental Research Funds for the Central Universities(WK2060000017)

Palladium-catalyzed intramolecular Heck tandem cyclization reactions were developed. With palladium iodide as a catalyst and 4-(dimethylamino)triphenylphosphine as a ligand, 3-substituted indoleamide derivatives were converted to bridged N-heterocyclic products in good yields under simple reaction conditions. The tandem reactions are featured by efficient construction of fused ring compounds in one pot and good functional group compatibility.

Key words: palladium catalyst, intramolecular Heck cyclization, bridged N-heterocyclic compound