Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (2): 631-640.DOI: 10.6023/cjoc202108050 Previous Articles     Next Articles



孙亚敏a, 李锡勇a, 袁金伟b,*(), 余加琳b, 刘帅楠b   

  1. a 威海海洋职业学院药品与医疗器械系 山东威海 264300
    b 河南工业大学化学化工学院 郑州 450001
  • 收稿日期:2021-08-26 修回日期:2021-09-26 发布日期:2022-02-24
  • 通讯作者: 袁金伟
  • 基金资助:
    河南省教育厅自然科学基金(21A150016); 河南省青年骨干教师基金(2018GGJS178); 河南工业大学自科创新基金支持计划(2020ZKCJ29)

CuI-Catalyzed Regioselective Synthesis of 3-Arylcoumarins with Arylamines under Mild Conditions

Yamin Suna, Xiyong Lia, Jinwei Yuanb(), Jialin Yub, Shuainan Liub   

  1. a Department of Pharmaceuticals and Medical Devices, Weihai Ocean Vocational College, Weihai, Shandong 264300
    b School of Chemistry & Chemical Engineering, Henan University of Technology, Zhengzhou 450001
  • Received:2021-08-26 Revised:2021-09-26 Published:2022-02-24
  • Contact: Jinwei Yuan
  • Supported by:
    Natural Science Foundation of Henan Provincial Department of Education(21A150016); Training Program of Youth Backbone Teacher of Henan Province(2018GGJS178); Innovative Funds Plan of Henan University of Technology(2020ZKCJ29)

A mild and convenient method has been developed for the construction of 3-arylcoumarins through CuI-catalyzed reaction of coumarins with arylamines under mild conditions. The present protocol simply utilizes readily available starting materials as substrates, inexpensive metal as catalyst, providing various 3-arylcoumarins with good functional groups toleration in moderate to good yields. Moreover, control experiments show that the reaction proceeds by a radical pathway.

Key words: coumarin, arylamine, copper-catalyzed, arylation, radical reaction