Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (12): 3979-3994.DOI: 10.6023/cjoc202209025 Previous Articles     Next Articles



肖潜a, 佟庆笑b, 钟建基b,*()   

  1. a 韩山师范学院化学与环境工程学院 广东潮州 521041
    b 汕头大学化学系 广东省有序结构材料的制备与应用重点实验室 广东汕头 515063
  • 收稿日期:2022-09-19 修回日期:2022-10-17 发布日期:2022-11-07
  • 通讯作者: 钟建基
  • 基金资助:
    国家自然科学基金(22171177); 国家自然科学基金(51973107)

Recent Progress on the Synthesis of Benzazepine Derivatives via Radical Cascade Cyclization Reactions

Qian Xiaoa, Qing-Xiao Tongb, Jian-Ji Zhongb()   

  1. a School of Chemistry and Environmental Engineering, Hanshan Normal University, Chaozhou, Guangdong 521041
    b Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Department of Chemistry, Shantou University, Shantou, Guangdong 515063
  • Received:2022-09-19 Revised:2022-10-17 Published:2022-11-07
  • Contact: Jian-Ji Zhong
  • Supported by:
    National Natural Science Foundation of China(22171177); National Natural Science Foundation of China(51973107)

Benzazepines are a kind of important seven-membered nitrogen-containing heterocyclic compounds, which are extensively exisited in natural products and pharmaceuticals, and have versatile biological activity. Therefore, great attention has been focused on the green and efficient synthesis of the benzazepines. In recent years, radical cascade cyclization reactions have gradually been developed as a powerful tool for the construction of benzazepines owing to their unique advantages. In this minireview, according to the different driving force of reaction, the research progress on the synthesis of benzazepines by radical cascade cyclization reactions in the past five years is systematically summarized in terms of photochemical reactions, electrochemical reactions and thermochemical reactions.

Key words: benzazepine derivatives, radical reaction, cascade cyclization reaction, visible-light photoredox catalysis