Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (11): 3606-3619.DOI: 10.6023/cjoc202205025 Previous Articles     Next Articles

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α-酮酸的脱羧酰基化/环化反应研究进展

吴业春, 于金涛*()   

  1. 常州大学石油化工学院 江苏常州 213164
  • 收稿日期:2022-05-17 修回日期:2022-06-23 发布日期:2022-07-05
  • 通讯作者: 于金涛
  • 基金资助:
    国家自然科学基金(21672028)

Recent Advances in the Decarboxylative Acylation/Cyclization of α-Keto Acids

Yechun Wu, Jintao Yu()   

  1. School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164
  • Received:2022-05-17 Revised:2022-06-23 Published:2022-07-05
  • Contact: Jintao Yu
  • Supported by:
    National Natural Science Foundation of China(21672028)

Decarboxylation of α-keto acids is a simple and efficient method to obtain corresponding acyl radicals. Cascade radical cyclization has been proved as efficient approach towards cyclic structures, especially heterocyclic ones. A variety of acylated cyclic compounds such as indolones, quinolinones, phenanthridines, coumarins, chromones, benzothiophenes, and pyrrole[1,2-a]indoles could be constructed using α-keto acids via the decarboxylative acylation/cyclization with acyl radicals as intermediates. This review focuses on the recent advances in the acylation/cyclization reaction triggered by acyl radicals that formed from the decarboxylation of α-keto acids.

Key words: α-keto acids, cyclization reaction, radical reaction, acylation