Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (6): 2026-2039.DOI: 10.6023/cjoc202211003 Previous Articles     Next Articles


任志军, 罗维纬, 周俊*()   

  1. 长沙理工大学化学化工学院 电力与交通材料保护湖南省重点实验室 细胞化学湖南省重点实验室 长沙 410114
  • 收稿日期:2022-11-02 修回日期:2022-11-16 发布日期:2023-01-05
  • 基金资助:
    国家自然科学基金(21801023); 湖南省自然科学基金(2021JJ40563); 长沙市科技局(kq2004070)

Recent Progress in Silver-Mediated Tandem Cyclization of N-Arylacrylamides

Zhijun Ren, Weiwei Luo, Jun Zhou*()   

  1. Hunan Provincial Key Laboratory of Cytochemistry, Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114
  • Received:2022-11-02 Revised:2022-11-16 Published:2023-01-05
  • Contact: E-mail:
  • Supported by:
    National Natural Science Foundation of China(21801023); Hunan Provincial Natural Science Foundation(2021JJ40563); Changsha Municipal Science and Technology Project(kq2004070)

As a star molecule, N-arylacrylamides can undergo tandem radical addition/cyclization to efficiently construct C(3)-disubstituted indolin-2-ones. Indolin-2-ones are a class of important heterocyclic compounds with a wide range of biological activities, and the synthesis of which has been a research hotspot in the field of organic chemistry and medicinal chemistry. Silver catalysts are low in toxicity, and have unique catalytic activities, which are widely used in organic synthesis. In this paper, starting from different radical precursors and bond types (C—C, C—N, C—P, C—S), the research progress of silver-mediated synthesis of C(3)-disubstituted indolin-2-ones via tandem radical addition/cyclization of N-arylacrylamides is reviewed, and the representative substrates and reaction mechanisms are also summarized and discussed.

Key words: silver-mediated reaction, N-arylacrylamides, tandem cyclization, C(3)-disubstituted indolin-2-ones