Silver-Catalyzed Tandem Radical Cyclization for the Synthesis of 3,3'-Disubstituted Oxindoles

doi:10.6023/cjoc201412030

Abstract

A new silver-catalyzed oxidative ring opening of cyclopropanols to functionalize alkenes of N-arylacrylamides leading to 3,3'-disubstituted oxindoles has been developed. This reaction is proposed to proceed through oxidative radical ring-opening and C—H functionalization cascade process under the mild reaction conditions with good functional groups tolerance.

Key words: silver-catalyzed, radical tandem cyclization, C—H functionalization, carbonyl-containing 3,3'-disubstituted oxindoles

Cite this article

Li Yonghong, Wang Junjiao, Wei Xiaohong, Yang Shangdong. Silver-Catalyzed Tandem Radical Cyclization for the Synthesis of 3,3'-Disubstituted Oxindoles[J]. Chin. J. Org. Chem., 2015, 35(3): 638-646.

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银催化的串联自由基环化合成3,3'-双取代氧化吲哚