Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (6): 1991-2001.DOI: 10.6023/cjoc202211024 Previous Articles     Next Articles


李格非a,b, 荆杰a, 罗振扬a, 默娟b, 熊德彩b, 叶新山b,*()   

  1. a 南京林业大学理学院 南京 210037
    b 北京大学药学院 天然药物及仿生药物国家重点实验室 北京 100191
  • 收稿日期:2022-11-22 修回日期:2022-12-26 发布日期:2023-01-11
  • 基金资助:
    国家自然科学基金(21907004); 国家自然科学基金(81821004); 天然药物及仿生药物国家重点实验室开放基金(K202216)

Recent Advances in Protection-Free Glycosylations

Gefei Lia,b, Jie Jinga, Zhenyang Luoa, Juan Mob, Decai Xiongb, Xinshan Yeb,*()   

  1. a School of Science, Nanjing Forestry University, Nanjing 210037
    b State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191
  • Received:2022-11-22 Revised:2022-12-26 Published:2023-01-11
  • Contact: E-mail:
  • Supported by:
    National Natural Science Foundation of China(21907004); National Natural Science Foundation of China(81821004); State Key Laboratory of Natural and Biomimetic Drugs(K202216)

Carbohydrates play a key role in many life activities, such as cell wall composition, energy storage and biological recognition. Development of highly regio- and stereo-selective glycosylation reactions is a central topic of current carbohydrate chemistry. The traditional glycosylation protocol usually requires the orthogonal protecting chemistry to obtain the selectivity of glycosylation reactions. Recent progress in protecting-group free strategies can provide a simple and mild approach to the chemo-selective construction of glycosidic bonds in oligosaccharides or glycoconjugates in aqueous conditions. The latest advances in protection-free chemical glycosylations are summarized, including the direct anomeric activation strategy developed by our group.

Key words: chemical glycosylation, protection-free, direct anomeric activation, carbohydrate chemistry