The Mannich reaction between 3-nitrobenzaldehyde (3-chlorobenzaldehyde), aromatic amines and aromatic ketones

Chin. J. Org. Chem. ›› 1996, Vol. 16 ›› Issue (3): 218-222. Previous Articles Next Articles

Original Articles

间硝基苯甲醛或间氯苯甲醛与芳香胺和芳香酮的Mannich反应

邹君华

西南师范大学化学化工学院

发布日期:1996-06-25

The Mannich reaction between 3-nitrobenzaldehyde (3-chlorobenzaldehyde), aromatic amines and aromatic ketones

ZOU JUNHUA

Published:1996-06-25

Abstract

In the presence of catalytic amount of hydrochloric acid, the Mannich reaction of 3-nitrobenzaldehyde (3-Chlorobenzaldehyde), aromatic amines and aromatic ketones can take place directly at 20~25℃. Fifteen corresponding Mannich bases (1a~1o), 1-aryl-3- arylamino [3-nitro(chloro) phenyl] acetone, were prepared with 68~87% yield. Some compounds were verified by elemental analysis, IR, ^1H NMR, MS. The reaction conditions were also discussed in this paper.

Key words: HYDROCHLORIC ACID, PROTON MAGNETIC RESONANCE SPECTROMETRY, AROMATIC AMINE, MANNICH REACTION, INFRARED SPECTROPHOTOMETRY

CLC Number:

O621

Cite this article

ZOU JUNHUA. The Mannich reaction between 3-nitrobenzaldehyde (3-chlorobenzaldehyde), aromatic amines and aromatic ketones[J]. Chin. J. Org. Chem., 1996, 16(3): 218-222.

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间硝基苯甲醛或间氯苯甲醛与芳香胺和芳香酮的Mannich反应

The Mannich reaction between 3-nitrobenzaldehyde (3-chlorobenzaldehyde), aromatic amines and aromatic ketones

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