CuBr2-Catalyzed Three-Component Coupling for Synthesis of Quinoline-2,4-dicarboxyl Derivatives

doi:10.6023/cjoc201401020

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (7): 1437-1441.DOI: 10.6023/cjoc201401020 Previous Articles Next Articles

Notes

CuBr₂催化的三组分反应合成喹啉-2,4-二羧基衍生物

王扣, 于浩飞, 丁林芬, 胡建林

昆明医科大学药学院暨云南省天然药物药理重点实验室昆明 650500

收稿日期:2014-01-13 修回日期:2014-03-12 发布日期:2014-04-15
通讯作者: 胡建林 E-mail:hujlkm@sina.com
基金资助:
云南省科技厅应用基础研究计划（No.2011FZ097）资助项目.

CuBr₂-Catalyzed Three-Component Coupling for Synthesis of Quinoline-2,4-dicarboxyl Derivatives

Wang Kou, Yu Haofei, Ding Linfen, Hu Jianlin

School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500

Received:2014-01-13 Revised:2014-03-12 Published:2014-04-15
Supported by:
Project supported by the Applied Basic Research Plan of Yunnan Province Science and Technology Department (No. 2011FZ097).

A convenient and efficient method for synthesizing quinoline-2,4-dicarboxyl derivatives has been developed via a simple one-pot reaction of aromatic amines, glyoxylic ester, and pyruvate using low-costing CuBr₂ as a catalyst. The method is atom efficiency, and utilizes non-expensive catalysts and easily available reagents, which provides an attractive approach to quinoline-2,4-dicarboxyl derivatives. This process has potential applications in the synthesis of biologically and medicinally relevant compounds.

Key words: quinoline-2,4-dicarboxyl derivatives, aromatic amines, glyoxylic ester, pyruvate, CuBr₂

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Wang Kou, Yu Haofei, Ding Linfen, Hu Jianlin. CuBr₂-Catalyzed Three-Component Coupling for Synthesis of Quinoline-2,4-dicarboxyl Derivatives[J]. Chin. J. Org. Chem., 2014, 34(7): 1437-1441.

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CuBr₂催化的三组分反应合成喹啉-2,4-二羧基衍生物

CuBr₂-Catalyzed Three-Component Coupling for Synthesis of Quinoline-2,4-dicarboxyl Derivatives

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CuBr2催化的三组分反应合成喹啉-2,4-二羧基衍生物