Synthesis and Crystal Structure of Adducty of Erythromycin and

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (06): 730-733. Previous Articles Next Articles

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红霉素9,11-亚胺醚和乙腈分子加合物的合成和晶体结构

史颖，姚国伟*，马敏

(北京理工大学生命科学与技术学院北京100081)

收稿日期:2004-03-22 修回日期:2004-12-20 发布日期:2005-05-30
通讯作者: 姚国伟

Synthesis and Crystal Structure of Adducty of Erythromycin and

SHI Ying, YAO Guo-Wei* , MA Min

(School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081)

Received:2004-03-22 Revised:2004-12-20 Published:2005-05-30
Contact: YAO Guo-Wei

Abstract

Erythromycin 9,11-iminoether, as a key intermediate, was obtained through controlling the condition of Beckmann rearrangement of erythromycin A (E) oxime. A stable molecular adduct can be formed from the title compound and acetonitrile with molar ratio of 1∶1. It is a transparent crystal characterized by monoclinic system and P2₁ space group. Contrasting the crystal structures between the title compound and erythromycin 6,9-iminoether reported in another paper, it would be useful to study the difference between the two isomers and the mechanism of Beckmann rearrangement and isomerization.

Key words: molecular adduct, erythromycin 9,11-iminoether, Beckmann rearrangement, crystal structure

Cite this article

SHI Ying, YAO Guo-Wei* , MA Min. Synthesis and Crystal Structure of Adducty of Erythromycin and[J]. Chin. J. Org. Chem., 2005, 25(06): 730-733.

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红霉素9,11-亚胺醚和乙腈分子加合物的合成和晶体结构

Synthesis and Crystal Structure of Adducty of Erythromycin and

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