Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (10): 1370-1377. Previous Articles     Next Articles




  1. (中国科学院上海有机化学研究所生命有机化学国家重点实验室 上海 200032)
  • 收稿日期:2006-05-29 修回日期:2006-07-19 发布日期:2006-09-19
  • 通讯作者: 伍贻康

A Survey of Synthesis of Antimycins

YANG Yong-Qing,WU Yi-Kang*   

  1. (State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemis-try,
    Chinese Academy of Sciences, Shanghai 200032)
  • Received:2006-05-29 Revised:2006-07-19 Published:2006-09-19
  • Contact: WU Yi-Kang

Antimycins are a large family of natural antibiotics featuring a nine-membered dilactone ring. The name of antimycin could be traced back to the late 1940’s. Since then, new antimycins are continuingly added to the list of this interesting class of compounds, which now already includes as many as 26 closely related individuals. Probably due to structural determination was mainly done on antimycin A3, synthetic endeavors up to now are carried out exclusively on the A3 (mostly A3b). The enantioselective syntheses spread over the last decades are reviewed, with the merits and shortcomings briefly discussed.

Key words: enantioselective synthesis, ring-closure, lactone, antibiotics