Efficient Synthesis of Alkylenedioxy-Bridged Bisdihydropyridines

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (12): 2115-2118. Previous Articles Next Articles

Original Articles

烷氧基桥联双二氢吡啶的简洁合成

柳冬梅 ; 杜丽婷 ; 孙晶; 颜朝国*

(扬州大学化学化工学院扬州 225002)

收稿日期:2008-02-24 修回日期:2008-04-24 发布日期:2008-12-28
通讯作者: 颜朝国

Efficient Synthesis of Alkylenedioxy-Bridged Bisdihydropyridines

LIU, Dong-Mei ; DU, Li-Ting ; SUN, Jing ; YAN, Chao-Guo*

(College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002)

Received:2008-02-24 Revised:2008-04-24 Published:2008-12-28
Contact: YAN, Chao-Guo

Abstract

One-pot multicomponent reactions of 2,2’-alkylenedioxy-bridged or 4,4’-alkylenedioxy-bridged dialdehydes with excess ethyl acetoacetate and ammonium bicarbonate gave alkylenedioxy-bridged bisdihydropyridines in high yields. The structures of the synthetic bisdihydropyridines were characterized with 1H NMR, 13C NMR and HRMS spectra, and one representative compound was further confirmed by determination of its single crystal structure.

Key words: dihydropyridine, one-pot reaction, aldehyde, single crystal, ethyl acetoacetate

Cite this article

LIU, Dong-Mei ; DU, Li-Ting ; SUN, Jing ; YAN, Chao-Guo*. Efficient Synthesis of Alkylenedioxy-Bridged Bisdihydropyridines[J]. Chin. J. Org. Chem., 2008, 28(12): 2115-2118.

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烷氧基桥联双二氢吡啶的简洁合成

Efficient Synthesis of Alkylenedioxy-Bridged Bisdihydropyridines

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