Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (01): 19-29.DOI: 10.6023/cjoc1104231 Previous Articles     Next Articles



李小娜, 张鹏亮, 段凯, 王家喜   

  1. 河北工业大学化工学院 天津 300130
  • 收稿日期:2011-04-23 修回日期:2011-06-10 发布日期:2011-08-24
  • 通讯作者: 王家喜 E-mail:jwang252004@126.COM
  • 基金资助:

    河北省自然科学基金(No. B2011202087)资助项目.

Recent Advance of Amino-acids and Their Derivatives as Chiral Ligands in Asymmetric Transfer Hydrogenation of Ketones

Li Xiaona, Zhang Pengliang, Duan Kai, Wang Jiaxi   

  1. School of Chemical Engineering, Hebei University of Technology, Tianjin 300130
  • Received:2011-04-23 Revised:2011-06-10 Published:2011-08-24
  • Contact: WANG Jia-Xi E-mail:jwang252004@126.COM
  • Supported by:

    Project supported by the Natural Science Foundation of Hebei Province (No. B2011202087).

The asymmetric transfer hydrogenation (ATH) reaction of prochiral ketones is an important method to produce chiral alcohols. Recently, the application of chiral amino acids and their derivatives as ligands in ATH of prochiral ketones promoted by the ruthenium, rhodium or iridium complexes have been attracted more attentions. Herein the catalytic properties of amino acids, amino acid based amides, thioamides, hydroxamic acids, hydrazides, amino alcohols and hydroxy amides as ligands in the ruthenium, rhodium or iridium catalyzed ATH of prochiral ketones have been overviewed.

Key words: chiral amino acid, derivative of amino acid, metal complex of amino acid, asymmetric transfer hydrogenation