Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (11): 2181-2186.DOI: 10.6023/cjoc201205006 Previous Articles     Next Articles



王湘波a, 简腾跃b, 马晓伟a, 何林a   

  1. a 石河子大学化学化工学院 新疆兵团化工绿色过程重点实验室-省部共建国家重点实验室培育基地石河子 832000;
    b 中国科学院化学研究所 北京分子科学国家实验室 中国科学院分子识别与功能重点实验室 北京 100190
  • 收稿日期:2012-05-07 修回日期:2012-07-04 发布日期:2012-07-09
  • 通讯作者: 何林
  • 基金资助:

    中国科学院分子识别与功能重点实验室2009年开放基金(No. 2009LMRF002)、石河子大学团队创新(No. 2011ZRKETD-0403)资助项目.

Synthesis of 2-Substituted Benzimidazoles Catalyzed by Cyclic Phosphoric Acid

Wang Xiangboa, Jian Tengyueb, Ma Xiaoweia, He Lina   

  1. a Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan and School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832000;
    b National Laboratory for Molecular Sciences, Chinese Academy of Sciences Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190
  • Received:2012-05-07 Revised:2012-07-04 Published:2012-07-09
  • Supported by:

    Project supported by the Key Laboratory of Molecular Recognition and Function, Chinese Academy of Sciences (No. 2009LMRF002), the Team Innovation Project of Shihezi University (No. 2011ZRKETD-0403).

In the presence of cyclic phosphoric acid, a series of 2-substituted benzimidazoles were synthesized by the reaction of o-phenylenediamine and aldehyde in tetrahydrofuran at room temperature. The influence of different catalysts, catalyst amount and solvent were investigated, the optimal reaction conditions were obtained and a possible mechanism was proposed. The reaction has the virtue of simple operation, mild reaction condition, high yield and environment friendliness.

Key words: o-phenylenediamine, aldehyde, cyclic phosphoric acid, benzimidazole