Synthesis of 2-Substituted Benzimidazoles Catalyzed by Cyclic Phosphoric Acid

doi:10.6023/cjoc201205006

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (11): 2181-2186.DOI: 10.6023/cjoc201205006 Previous Articles Next Articles

Notes

环状磷酸催化合成2-取代苯并咪唑

王湘波^a, 简腾跃^b, 马晓伟^a, 何林^a

a 石河子大学化学化工学院新疆兵团化工绿色过程重点实验室-省部共建国家重点实验室培育基地石河子 832000;
b 中国科学院化学研究所北京分子科学国家实验室中国科学院分子识别与功能重点实验室北京 100190

收稿日期:2012-05-07 修回日期:2012-07-04 发布日期:2012-07-09
通讯作者: 何林 E-mail:helin@shiu.edu.cn
基金资助:
中国科学院分子识别与功能重点实验室2009年开放基金(No. 2009LMRF002)、石河子大学团队创新(No. 2011ZRKETD-0403)资助项目.

Synthesis of 2-Substituted Benzimidazoles Catalyzed by Cyclic Phosphoric Acid

Wang Xiangbo^a, Jian Tengyue^b, Ma Xiaowei^a, He Lin^a

a Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan and School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832000;
b National Laboratory for Molecular Sciences, Chinese Academy of Sciences Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190

Received:2012-05-07 Revised:2012-07-04 Published:2012-07-09
Supported by:
Project supported by the Key Laboratory of Molecular Recognition and Function, Chinese Academy of Sciences (No. 2009LMRF002), the Team Innovation Project of Shihezi University (No. 2011ZRKETD-0403).

In the presence of cyclic phosphoric acid, a series of 2-substituted benzimidazoles were synthesized by the reaction of o-phenylenediamine and aldehyde in tetrahydrofuran at room temperature. The influence of different catalysts, catalyst amount and solvent were investigated, the optimal reaction conditions were obtained and a possible mechanism was proposed. The reaction has the virtue of simple operation, mild reaction condition, high yield and environment friendliness.

Key words: o-phenylenediamine, aldehyde, cyclic phosphoric acid, benzimidazole

Cite this article

Wang Xiangbo, Jian Tengyue, Ma Xiaowei, He Lin. Synthesis of 2-Substituted Benzimidazoles Catalyzed by Cyclic Phosphoric Acid[J]. Chin. J. Org. Chem., 2012, 32(11): 2181-2186.

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环状磷酸催化合成2-取代苯并咪唑

Synthesis of 2-Substituted Benzimidazoles Catalyzed by Cyclic Phosphoric Acid

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