Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (06): 1135-1143.DOI: 10.6023/cjoc201304001 Previous Articles     Next Articles

Articles

一些特异生境微生物的化学成分及其抗肿瘤活性研究

李瑶瑶, 沈月毛   

  1. 山东大学药学院 济南 250012
  • 收稿日期:2013-04-01 修回日期:2013-05-06 发布日期:2013-05-08
  • 通讯作者: 沈月毛 E-mail:yshen@sdu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.81273384, 31028019, 90913024, 30500632, 30430020, 30325044, 30070007)资助项目.

Chemical Components of Some Microorganisms Isolated from Specific Habitats and Their Antitumor Activities

Li Yaoyao, Shen Yuemao   

  1. Schoole of Pharmaceutical Sciences, Shandong Univercity, Jinan 250012
  • Received:2013-04-01 Revised:2013-05-06 Published:2013-05-08
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.81273384, 31028019, 90913024, 30500632, 30430020, 30325044, 30070007).

The discovery of new anti-tumor drugs is a pressing and continual need for human health due to the constant emergence of drug resistant tumor cell lines, and the rising occurrence of cancer.In recent years, researchers are paying more and more attention to the chemical components of microorganisms isolated from specific habitats and their bioactivities.Our group isolated a large number of new bioactive natural products, most with complex structures, from endophytes of medicinal plants and marine microbes.Moreover, the antitumor mechnisms and targets of two classes of compounds were investigated.Our results indicated that these special microbes are of great potential for new bioactive compounds and deserve further explorations.

Key words: endophytes of medicinal plant, marine microbes, natural product, anti-tumor action