Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (9): 2728-2744.DOI: 10.6023/cjoc202204009 Previous Articles     Next Articles



孔祥凯a,b, 张逸鹏a, 党菱婧c, 陈文a,*(), 张洪彬a,*()   

  1. a 云南大学化学科学与工程学院 教育部自然资源药物化学重点实验室 昆明 650091
    b 贵州医科大学贵州省化学合成药物研发利用工程技术研究中心 贵阳 550025
    c 德宏职业学院医学技术学院 云南德宏 678400
  • 收稿日期:2022-04-08 修回日期:2022-05-31 发布日期:2022-06-08
  • 通讯作者: 陈文, 张洪彬
  • 基金资助:
    长江学者和创新团队发展计划(IRT17R94); 国家自然科学基金(U1702286); 国家自然科学基金(21762047); 国家自然科学基金(21901224); 云南省基础研究计划(2019FI018); 云南省科技领军人才(202005AB160003); 云南省青年拔尖人才(YNWR-QNBJ-2018-025)

Research Progress in Synthesis of Indole Alkaloids Vindoline and Vindorosine

Xiangkai Konga,b, Yipeng Zhanga, Lingjing Dangc, Wen Chena(), Hongbin Zhanga()   

  1. a Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091
    b Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550025
    c School of Medical Technology, Dehong Vocational College, Dehong, Yunnan 678400
  • Received:2022-04-08 Revised:2022-05-31 Published:2022-06-08
  • Contact: Wen Chen, Hongbin Zhang
  • Supported by:
    Program for Changjiang Scholars and Innovative Research Team in University(IRT17R94); National Natural Science Foundation of China(U1702286); National Natural Science Foundation of China(21762047); National Natural Science Foundation of China(21901224); Yunnan Fundamental Research Projects(2019FI018); Ling-Jun Scholars of Yunnan Province(202005AB160003); Talent Plan of Yunnan Province(YNWR-QNBJ-2018-025)

Vindoline and vindorosine are two Aspidosperma-type indole alkaloids isolated from the leaves of Catharanthus roseus. Both compounds have highly functionalized pentacyclic indoline skeleton and six contiguous stereogenic centers, three of which are congested quaternary carbon centers. In view of the complex structures of these two molecules and their great challenges in synthesis, 15 research groups have carried out the synthesis of these two molecules. The progress of the synthesis of these two molecules in chronological order is reviewed.

Key words: vindoline, vindorosine, natural product, total synthesis