Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (4): 1033-1039.DOI: 10.6023/cjoc201612039 Previous Articles     Next Articles


多形炭角菌Xylaria polymorpha菌丝发酵的次级代谢产物研究

杨宁宁a,b, 孔凡栋b, 马青云b, 黄圣卓b, 罗都强c, 周丽曼b, 戴好富b, 郁志芳a, 赵友兴b   

  1. a. 南京农业大学食品科技学院 南京 210095;
    b. 中国热带农业科学院热带生物技术研究所 海口 571101;
    c. 河北大学生命科学学院 教育部药物化学与分子诊断教育部重点实验室 保定 071002
  • 收稿日期:2016-12-12 修回日期:2016-12-22 发布日期:2017-01-04
  • 通讯作者: 郁志芳, 赵友兴;
  • 基金资助:


Chemical Constituents from the Cultures of Fungus Xylaria polymorpha

Yang Ningninga,b, Kong Fandongb, Ma Qingyunb, Huang Shengzhuob, Luo Duqiangc, Zhou Limanb, Dai Haofub, Yu Zhifanga, Zhao Youxingb   

  1. a. College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095;
    b. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101;
    c. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, College of Life Science, Baoding 071002
  • Received:2016-12-12 Revised:2016-12-22 Published:2017-01-04
  • Contact: 10.6023/cjoc201612039;
  • Supported by:

    Project supported by the Special Fund for Agro-Scientific Research in the Public Interest (No. 201303117), the Fundamental Scientific Research Funds for Chinese Academy of Tropical Agricultural Sciences (No. 1630052016008) and the Natural Science Foundation of Hainan Province (No. 20153143).

Totally 21 compounds were isolated from the EtOAc extract of fermentation broth of fungus Xylaria polymorpha (Pers.: Fr.) Grer, including two new drimane-type sesquiterpenoids named polymorphines A and B (1~2) and one new phenyloxolane compound named 2-methyl-2-(4-hydroxymethylphenyl) oxolane (3), together with 18 known compounds 4~21. The structures of these compounds were elucidated by NMR and single-crystal X-ray diffraction analysis. Compound 2 exhibited anti-acetylcholinesterase and α-glucosidase inhibitory activities. Moreover, compound 3 showed moderate inhibitory activitiy against the nematode Panagrellus redivivus with mortality ratio of 59.6% at 2.5 mg/mL.

Key words: Xylaria polymorpha, sesquiterpene, AChE inhibitory activity, α-glucosidase inhibitory activity, anti-nematode activity