Research Progress in Structural Modification of Antimycin A

doi:10.6023/cjoc201702010

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (6): 1368-1381.DOI: 10.6023/cjoc201702010 Previous Articles Next Articles

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抗霉素A结构改造的研究进展

程华^a, 聂忍^a, 汪万强^a, 黄琳^a, 刘科^a, 陈宬^c, 吴琼友^b

a. 湖北文理学院化学化工与食品科学学院襄阳 441053;
b. 华中师范大学化学学院农药与化学生物学教育部重点实验室武汉 430079;
c. 武汉理工大学材料复合新技术国家重点实验室武汉 430070

收稿日期:2017-02-09 修回日期:2017-03-03 发布日期:2017-03-08
通讯作者: 吴琼友,陈宬 E-mail:qywu@mail.ccnu.edu.cn;chengchen@whut.edu.cn
基金资助:
国家自然科学基金（Nos.21472063，21502062）、湖北省教育厅一般项目（No.Q20102606）、襄阳市科技局一般项目（No.2010GG1B33）和低维光电材料与器件湖北省重点实验室（No.HLOM151005）资助项目.

Research Progress in Structural Modification of Antimycin A

Cheng Hua^a, Nie Ren^a, Wang Wanqiang^a, Huang Lin^a, Liu Ke^a, Chen Cheng^c, Wu Qiongyou^b

a. Department of Chemical Engineering and Food Science, Hubei Universtry of Arts and Science, Xiangyang 441053;
b. Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079;
c. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070

Received:2017-02-09 Revised:2017-03-03 Published:2017-03-08
Contact: 10.6023/cjoc201702010 E-mail:qywu@mail.ccnu.edu.cn;chengchen@whut.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21472063, 21502062), the Hubei Provincial Department of Education (No. Q20102606), the Xiangyang Science and Technology Bureau (No. 2010GG1B33), and the Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices (No. HLOM151005).

Antimycin A is a class of natural products bearing a dilactone-ring moiety as the core skeleton. These compounds have been identified as specific inhibitors of the mitochondrial respiratory chain and bind to the Q_i site of the cytochrome bc₁ complex. Due to its unique structure and extremly high activity, it has aroused great interest of researchers. The development and biological activities of antimycin A are mainly described, and the recent results of its structural modifications are summarized.

Key words: antimycin A, inhibitor, biological activity, structural modification

Cite this article

Cheng Hua, Nie Ren, Wang Wanqiang, Huang Lin, Liu Ke, Chen Cheng, Wu Qiongyou. Research Progress in Structural Modification of Antimycin A[J]. Chin. J. Org. Chem., 2017, 37(6): 1368-1381.

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抗霉素A结构改造的研究进展

Research Progress in Structural Modification of Antimycin A

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