Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (6): 1368-1381.DOI: 10.6023/cjoc201702010 Previous Articles     Next Articles



程华a, 聂忍a, 汪万强a, 黄琳a, 刘科a, 陈宬c, 吴琼友b   

  1. a. 湖北文理学院化学化工与食品科学学院 襄阳 441053;
    b. 华中师范大学化学学院 农药与化学生物学教育部重点实验室 武汉 430079;
    c. 武汉理工大学材料复合新技术国家重点实验室 武汉 430070
  • 收稿日期:2017-02-09 修回日期:2017-03-03 发布日期:2017-03-08
  • 通讯作者: 吴琼友,陈宬;
  • 基金资助:


Research Progress in Structural Modification of Antimycin A

Cheng Huaa, Nie Rena, Wang Wanqianga, Huang Lina, Liu Kea, Chen Chengc, Wu Qiongyoub   

  1. a. Department of Chemical Engineering and Food Science, Hubei Universtry of Arts and Science, Xiangyang 441053;
    b. Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079;
    c. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070
  • Received:2017-02-09 Revised:2017-03-03 Published:2017-03-08
  • Contact: 10.6023/cjoc201702010;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21472063, 21502062), the Hubei Provincial Department of Education (No. Q20102606), the Xiangyang Science and Technology Bureau (No. 2010GG1B33), and the Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices (No. HLOM151005).

Antimycin A is a class of natural products bearing a dilactone-ring moiety as the core skeleton. These compounds have been identified as specific inhibitors of the mitochondrial respiratory chain and bind to the Qi site of the cytochrome bc1 complex. Due to its unique structure and extremly high activity, it has aroused great interest of researchers. The development and biological activities of antimycin A are mainly described, and the recent results of its structural modifications are summarized.

Key words: antimycin A, inhibitor, biological activity, structural modification