Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3213-3219.DOI: 10.6023/cjoc201707005 Previous Articles     Next Articles



岑竞鹤a, 杨凯b, 李建晓a, 李灿a, 杨少容a   

  1. a 华南理工大学化学与化工学院 广州 510640;
    b 赣南医学院药学院 赣州 341000
  • 收稿日期:2017-07-05 修回日期:2017-08-16 发布日期:2017-08-18
  • 通讯作者: 李建晓, 杨少容;
  • 基金资助:


Direct 3-Arylsulfenylation of Indoles with Thiols in Basic Ionic Liquid

Cen Jinghea, Yang Kaib, Li Jianxiaoa, Li Cana, Yang Shaoronga   

  1. a School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640;
    b School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000
  • Received:2017-07-05 Revised:2017-08-16 Published:2017-08-18
  • Contact: 10.6023/cjoc201707005;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21502055, 21642005), the Fundamental Research Funds for the Central Universities (No. 2015ZM150) and the China Postdoctoral Science Foundation (No. 2016T90779).

An efficient and convenient transition metal-free procedure for the synthesis of 3-sulfenylindoles derivatives in moderate to good yields from readily available indoles and thiols in basic ionic liquid has been developed. Their structures were confirmed by 1H NMR, 13C NMR and HRMS. This sulfenylation process provides a novel route for directly accessing 3-sulfenylindoles in good to excellent yields and good functional group tolerance with high atom efficiency. Notably, the current methodology could also be conveniently applied to the synthesis of thioarylated naturally occurring biologically active frameworks.

Key words: ionic liquids, indoles, thiols, 3-arylsulfenylation reaction