Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (11): 3289-3293.DOI: 10.6023/cjoc201903035 Previous Articles     Next Articles


张茂生a, 令狐浪a, 张建永a, 聂绪强a, 李晓飞b, 郭大乐c, 肖世基ab*()   

  1. a遵义医科大学药学院 贵州遵义 563006
    b 贵州省兰科药用植物繁育及高效应用工程研究中心 贵州遵义 563006
    c 成都中医药大学药学院 成都 611137
  • 收稿日期:2019-03-20 发布日期:2019-07-03
  • 通讯作者: 肖世基
  • 基金资助:

Bibenzyl Derivatives from Dendrobium nobile

Zhang Maoshenga, Linghu Langa, Zhang Jianyonga, Nie Xuqianga, Li Xiaofeib, Guo Dalec, Xiao Shijiab*()   

  1. a School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563006
    b Guizhou Provincial Research Center for the Propagation and Efficient Utilization of Medicinal Orchids, Zunyi, Guizhou 563006
    c School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137
  • Received:2019-03-20 Published:2019-07-03
  • Contact: Xiao Shiji
  • Supported by:
    the National Natural Science Foundation of China(31560102);the Key Technologies R & D Program of Guizhou Province(黔科合重大专项字[2015]6010-2)

By silica gel, MCI column chromatographic and preparative high performance liquid chromatography (HPLC) technologies, three new bibenzyl derivatives were isolated from the tubes of Dendrobium nobile. One racemic compound was further purified by chiral (HPLC) to obtain a pair of enantiomers 1a and 1b, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. By using spectroscopic techniques including NMR and HR-ESIMS, the structures of compounds 1~3 were identified as didendronbiline A (1), dendronbiline B (2), and dendronbiline C(3).

Key words: dendrobium nobile, orchidaceae, bisbibenzyl, dendronbiline