“On Water” Nucleophilic Addition of Pyrazolones to Trifluoromethyl Ketones

doi:10.6023/cjoc201910038

Abstract

A green and efficient nucleophilic addition reaction of trifluoromethyl ketone with pyrazolone was developed under "on water" conditions, affording pyrazolone substituted tertiary trifluoromethyl alcohols in high yields. The advantages of being catalyst-free, column chromatography-free, environmentally benign and easy workup make it a promising method for preparation of a variety of pyrazolone substituted tertiary trifluoromethyl alcohols.

Key words: “on water” reaction, nucleophilic addition, pyrazolone, trifluoromethyl ketone

Cite this article

Luo Liang, Cao Xiaomei, Lai Guowei, Liu Jinxiang, Luo Haiqing, Lu Dongliang, Zhang Yong. “On Water” Nucleophilic Addition of Pyrazolones to Trifluoromethyl Ketones[J]. Chinese Journal of Organic Chemistry, 2020, 40(5): 1323-1330.

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