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化学学报
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化学学报 ›› 1954, Vol. 20 ›› Issue (2): 140-143. 上一篇    下一篇

论文

用麦胺酸拆开消旋-反式-1-对硝基苯-2-氨基-1,3-丙二醇

高怡生, 陆顺兴   

  1. 中国科学院药物研究所
  • 投稿日期:1954-07-16 发布日期:2013-06-04

RESOLUTION OF DL-THREO-1-P-NITROPHENYL-2-AMINO-1, 3-PROPANEDIOL WITH L-AND D-GLUTAMIC ACID

KAO YEE-SHENG, LOH SHUEN-HSING   

  1. Institute of Materia Medica, Academia Sinica
  • Received:1954-07-16 Published:2013-06-04

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638

被引次数

2

消旋-反式-1-对硝基苯-2-氨基-1,3-丙二醇(I),可用L-型及D-型麸胺酸为拆开剂,拆开其D-及L-反式-(I)。LL-及DD-麸胺酸盐在稀酒精中的溶解度较LD-及DL麸胺酸盐为小。故用D-麸胺酸为拆开剂,可以获得产量较高的拆开。

The resolution of DL-threo-1-p-nitrophenyl-2-amino-1,3-propanediol (I) with natural L-glutamic acid as well as synthetic D-glutamic acid has been described. The L-(I)-L-glutamate and D-(I)-D-glutamate are less soluble in dilute alcohol than D-(I)-L-glutamate and L-(I)-D-glutamate. The D-threo-(I) liberated from D-(I)-Land D-(I)-D-glutamate is identical in melting point and specific rotation as that described in literature.