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化学学报
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化学学报 ›› 1957, Vol. 23 ›› Issue (5): 361-366. 上一篇    下一篇

论文

X射线对比剂Ⅲ.α-乙基-2,4,6-三卤-3-氨基肉桂酸及其衍生物的合成

趙緜, 胡炳晟   

  1. 中国协和医学院生物化学系 北京
  • 投稿日期:1957-04-01 发布日期:2013-06-03

X-RAY CONTRAST MEDIUM Ⅲ.SYNTHESIS OF α-ETHYL-2, 4, 6-TRIHALO-3-AMINO-CINNAMTC ACID AND THEIR DERIVATIVES

CHAO MIEN(MIEN CHAO), HU PING-CHENG   

  1. Department of Biochemistry, Chinese Union Medical College
  • Received:1957-04-01 Published:2013-06-03

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为了制备满意的胆囊X射线对比剂,本文合成了α-乙基-2,4,6-三卤-3-氨基肉桂酸及其乙酰及丁酰衍化物。在动物造影试验中这些三卤肉桂酸衍化物可得到良好的显影结果,这说明双键对显影的影响不大。

For the preparation of cholecystographic substances, we synthesized a-ethyl-maminocinnamic acid (Ⅶ) from a-ethyl-m-nitre-cinnamic acid (Ⅵ) by reduction (1) with ferrous sulfate, and (2) with hydrogen sulfide.Both methods of reduction gave good yield.