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化学学报
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化学学报 ›› 1966, Vol. 32 ›› Issue (2): 186-190. 上一篇    下一篇

论文

Ⅴ.N4-[5’-(3’-甲硫基-6’-甲基)-1’,2’,4’-三嗪基]-3-甲硫基-5-氧代-6-甲基-4,5-二氢-1,2,4-三嗪的胺解反应

李钧, 张礼和, 王序   

  1. 北京医学院药学系
  • 投稿日期:1965-03-12 发布日期:2013-06-03

Ⅴ.AMINOLYSIS OF N4-[5’-(3’-METHYLMERCAPTO-6’-METHYL)-1’,2’,4’-TRIAZINYL]-3-METHYLMERCAPTO-5-OXO-6-METHYL-4,5-DIHYDRO-1,2,4-TRIAZINE

LI CHUN, CHANG LI-Ho, WANG HSIU   

  1. Peking Medical College
  • Received:1965-03-12 Published:2013-06-03

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N4-[5'-(3'-甲硫基-6'-甲基)-1',2',4'-三嗪基-3-甲硫基-5-氧代-6-甲基-4,5-二氢-1,2,4-三嗪(Ⅱ)在乙醇中与一系列胺反应,得3-甲硫基-5-取代胺基-6-甲基-1,2,4-三嗪(Ⅲa-h)及3-甲硫基-5-羟基-6-甲基-1,2,4-三嗪(Ⅰ);Ⅱ在同样条件下,与碱性弱或空间障碍较大的对硝基苯胺、邻氯苯胺及邻甲苯胺不发生反应;Ⅱ与氨,异丁胺反应,尚得到3-取代胺基-5-羟基-6-甲基-1,2,4-三嗪(Ⅳa,b).

When aminolysis of N4-[5'-(3'-methylmercapto-6'-methyl)-1', 2',4'-triazinyl]-3-methylmercapto-5-oxo-6-methyl-4,5-dihydro-1,2,4-triazine (Ⅱ) with a series of aliphatic and aromatic amines was conducted in hot ethanol, 5-substituted amino-3-methylmercapto-6-methyl-1,2,4triazines (Ⅲa-b) and 3-methylmercapto-5-hydroxy-6-methyl-1,2,4-triazine (Ⅰ) were obtained (Table 1).No reaction took place with p-nitroaniline, o-chloroaniline, or with o-toluidine.When compound (Ⅱ) reacted with isobutylamine or with ammonia in hot ethanol, 3-isobutylamino-5-hydroxy-6-methyl-1,2,4-triazine (Ⅳa) or 3-amino-5-hydroxy-6-methyl-1,2,4triazine (Ⅳb) was obtained respectively in addition to the 5-substituted amino-3-methyhnercapto6-methyl-1,2,4-triazine (Ⅲd,e) and 3-methylmercapto-5-hydroxy-6-methyl-1,2,4-triazine (Ⅰ).