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化学学报
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化学学报 ›› 1980, Vol. 38 ›› Issue (6): 596-600. 上一篇    下一篇

研究简报

醇酮环合法合成dl-麝香酮

姚乾元1, 陈雪1, 高兆润2, 赵文芝2   

  1. 1. 山东省中医药研究所 济南;
    2. 济南人民制药厂
  • 投稿日期:1978-12-13 发布日期:2013-06-03

SYNTHESIS OF dl-MUSCONE THROUGH ACYLOIN CYCLIZATION

YAO QIAN-YUAN1, CHEN XUE1, GAO ZHAO-YUN2, ZHAO WEN-ZHI2   

  1. 1. Shandong Institute of Traditional Chinese Medicine, Jinan;
    2. Jinan People's Pharmaceutical Factory
  • Received:1978-12-13 Published:2013-06-03

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麝香酮(β-甲基环十五烷酮)是天然麝香的组成成分,并具有天然麝香某些重要的药理作用,本文报道它的合成工艺和纯化的研究。有关麝香酮的合成方法,国内外报道很多[1]。我们选用α,ω-长链二元酸酯进行醇酮环合法制备dl-麝香酮。早先Stoll和Commarmont[2]报道用β-甲基十五烷二酸双乙酯经醇酮环合法合成dl-麝香酮。

dl-Muscone was prepared through acyloin cyclization of dimethyl β-methyl-pentadecanedioate,which was synthesized from anodio coupling of half methyl ester of dodecanedioic acid and that of,β-methylglutaric aoid.Separtion of dl-muscone from its isomerio γ-methyl compound was achieved by silica-gel column chromatography,The result shows that ratio between dl-muscone and its γ-methyl isomer is about 7:3.