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化学学报
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化学学报 ›› 1981, Vol. 39 ›› Issue (5): 427-432. 上一篇    下一篇

论文

云南美登木活性成分的研究 Ⅰ.抗癌成分美登素和美登普林的分离和鉴定

周韵丽1, 黄丽瑛1, 周倩如1, 蒋福祥1, 贺贤国1, 李朝明2, 王春2, 李炳钩2   

  1. 1. 中国科学院上海药物研究所;
    2. 中国科学院云南热带植物研究所 昆明
  • 投稿日期:1979-06-22 发布日期:2013-06-03

STUDIES ON THE ACTIVE PRINCIPLES OF MAYTENUS HOOKERILOES Ⅰ. ISOLATION AND CHARACTERIZATION OF TWO ANTITUMOR PRINCIPLES——MAYTANSINE AND MAYTANPRINE

ZHOU YUN-LI1, HUANG LI-YING1, ZHOU QIAN-RU1, JIANG FU-XIANG1, HE XIAN-GUO1, LI CHAO-MING2, WANG CHUN2, LI BING-JUN2   

  1. 1. Shanghai Institute of Materia Medica, Academia Sinica;
    2. Yunnan Institute of Tropical Botany, Academia Sinica, Kunming
  • Received:1979-06-22 Published:2013-06-03

PDF

1133

被引次数

10

从云南美登木(Maytenus hookeri Loes)茎中,分到两个抗肿瘤活性很强的微量成分,通过理化分析和紫外、红外、核磁共振谱及质谱测定,分别证实为美登素(maytansine)和美登普林(maytanprine)。

Two minor bnt potent antitumor orystalline principles 1 and 2 have been isolated from the stems of Maytenus hookeri Loes.They show significant inhibitory activity against Ehrlich aeoites tumor in vivo at the dosage of 20-25 μg/kg level.According to the chemical and spectroscopic data they were identified as mayta,nsine and maytanprine respectively.