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化学学报
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化学学报 ›› 1982, Vol. 40 ›› Issue (4): 321-324. 上一篇    下一篇

论文

通光藤中一个新C21甾族化合物的化学结构测定

罗思齐1, 徐光漪1, 易大年1, 金惠芳1, 贾振魁2, 毛天宝2   

  1. 1. 上海医药工业研究院;
    2. 中国人民解放军昆明军区后勤部军事医学研究所
  • 投稿日期:1980-05-19 发布日期:2013-06-03
  • 通讯作者: 罗思齐

THE DETERMINATION OF THE CHEMICAL STRUCTURE OF TENACISSIGENIN——A NEW C21 STEROID FROM MARSDENIA TENACISSIMA(ROXB.)WIGHT ET ARN.

LUO SI-QI1, XU GUANG-YI1, YI DA-NIAN1, JIN HUI-FANG1, JIA ZHEN-KUI2, MAO TIAN-BAO2   

  1. 1. Shanghai Research Institute of Pharmaceutical Industry;
    2. Kunming Research Institute of Military Medicine
  • Received:1980-05-19 Published:2013-06-03

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从通光藤中分离到一个新的C21甾族化合物(晶A),通过物理和化学方法确定了它的结构.该甾族化合物的结构特点为B,C环系顺式镶合,缩酮的两个氧环与C,D环共同组成了一个牢固的笼式结构,这是天然化合物中比较少见的一种结构.晶A命名为通光素,其化学名称为5α,17α-孕甾-3β,8α,11α,12β,14β-五醇-20-酮-8,11-缩酮.

A new C21 steroid (compound A) has been isolated from Marsdanid tendcissszma (Roxb.) Wight et Arn.(Aedepiadaoeae).The molecular formula of compound A is 21H32O5 Compound A does not show carbonyl absorption and olefinio proton resonance in its IR and NMR spectra which is quite different from commonly oooured Ca21 steroids.The five oxygen atoms in compound A have been proved to be present as three hydroxyl group and two ozygen containing rings.By means of chemical and spectroscopic analysis as well as X-ray diffraction method,the ahemioal structure of compound A has been determined as 5α,17α-pregnane-3β,8α,11α,12β,14β-pentaol-20-one-8,11-ketal(3),in which ring B and ring C are cis fused.Moreover,ring C and ring D together with the ketal rings form a rigid cage in this compound.Compound A has been named tenaoissigenin.