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化学学报
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化学学报 ›› 1987, Vol. 45 ›› Issue (3): 295-297. 上一篇    下一篇

研究论文

β,β-二氯丁烯酮甲基上的反应

何森泉   

  1. 云南大学化学系
  • 发布日期:1987-03-15

Reactions occurring on the methyl group of \b\,b-dichlorobutenone

HE SENGQUAN   

  • Published:1987-03-15

PDF

395

被引次数

7

通过4,4-二氯-3-丁烯-2-酮的氯甲基化,Mannich反应和醇醛缩合制备了1,1,5-三氯-p-戊烯-3-酮(2),1,1-二氯-9-二乙胺基-1-戊烯-3-酮盐酸盐(3)和1,1-二氯-1,4-己二烯-3-酮(4).氯甲基化产品(2)与三乙胺在醚反应生成1,1-二氯-1,4-戊二烯-3-酮(6),在醇中生成1,1-二氯-5-乙氧基-1-戊烯-3-酮(6).与容易在室温中聚合.(2)和氨在醇中反应可得到环化产品N-(4-酮基-5H,6H-2-吡啶基)-3H,4H,5H-吡啶-2,4-二酮.

关键词: 缩合反应, 醚, 氯代烃, 乙醇 P, 曼尼希反应, 戊二烯 P, 吡啶酮 P, 烯酮, 丁烯酮 P, 己二烯 P

1,1,5-Trichloropent-1-en-3-one (I), 1,1-dichloro-5-(diethylamino)pent-1-en-3-one hydrochloride and 1,1-dichloro-1,4-hexadien-3-one were prepared resp. by means of chloromethylation, Mannich reaction and aldol condensation of 4,4-dichlorobut-3-en-2-one. The chloromethylation product I reacted with triethylamine to give 1,1-dichloro-1,4-pentadien-3-one (II) in ether and 1,1-dichloro-5-ethoxypent-1-en-3-one in alcohol II polymd. easily at room temperature Reaction of I with ammonia in EtOH gave pyridinone III.

Key words: CONDENSATION REACTION, ETHER, CHLOROHYDROCARBON, ETHANOL P, MANNICH REACTION, PENTADIENE P, PYRIDINONE P, KETENE, BUTENONE P, HEXADIENE P

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