化学学报 ›› 1989, Vol. 47 ›› Issue (5): 506-508. 上一篇    下一篇

研究论文

新生物碱10-羟基脱氧喜树碱

林隆泽;沈积慧;周彤;沈春镒;柯珉珉   

  1. 中国科学院上海药物研究所
  • 发布日期:1989-05-15

New alkaloid: 10-hydroxydeoxycamptothecin

LIN LONGZE;SHEN JIHUI;ZHOU TONG;SHEN CHUNYI;KE MINMIN   

  • Published:1989-05-15

本文报道从羟基喜树碱的母液中分离剂, 新生物碱10-羟基脱氧喜树碱(1), 从园二色谱分析, 在天存在的A环氧取代喜树碱类化合物20-C具有和喜树碱一样的S构型, 而天然存在的脱氧喜树碱类化合物20C具有R构型, 即与喜树碱相反的绝对构型.

关键词: 生物碱, 羟基, 圆振二向色性, 喜树硷

A new alkaloid (I) was isolated from the seeds of Camptotheca acuminata Decne. It was identified as 10-hydroxydeoxycamptothecin with a 20R-configuration by spectral anal. and chem. transformation. It shows a strong cytotoxicity against P388 leukemia cell.

Key words: ALKALOID, HYDROXY GROUP, CIRCULAR DICHROISM, CAMPTOTHECINUM

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