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化学学报
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化学学报 ›› 1989, Vol. 47 ›› Issue (8): 756-759. 上一篇    下一篇

研究论文

用核磁共振二维谱分析吗啡的构型和氢键

王德华;许肖龙;Levy, G.C   

  1. 中国科学院武汉物理研究所;美国锡腊丘斯大学化学系
  • 发布日期:1989-08-15

Analysis of the structure, configuration and hydrogen bonding of morphine by two dimensional NMR spectroscopy

WANG DEHUA;XU XIAOLONG;Levy, G.C   

  • Published:1989-08-15

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1379

被引次数

2 | 3

本文用核磁共振二维谱技术证明了吗啡质子谱的谱线归属和分子构型, 用NOESY技术发现了溶剂分子与溶质分子之间形成氢键的空间构型。

关键词: 吗啡, 弛豫, 化学位移, 氢键, 构型, 二维核磁共振谱法

Assignments of 13C and 1H spectra of morphine and codeine have been confirmed by heteronuclear chem. shift correlated and NOESY techniques. The configuration features of morphine were analyzed, particularly the configuration of hydrogen bonding between the morphine nitrogen and the solvent impurity CHD2OH. The NOESY experiments clearly showed the cross peaks between the proton of hydrogen bonding and the protons above the piperidine ring of morphine. These cross peaks imply that the hydrogen bonding is above the piperidine ring.

Key words: MORPHINUM, RELAXATION, CHEMICAL SHIFT, HYDROGEN BONDS, CONFIGURATION, 2D NMR SPECTROMETRY

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