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化学学报
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化学学报 ›› 1990, Vol. 48 ›› Issue (3): 275-277. 上一篇    下一篇

研究论文

青蒿素生物合成的研究1. 青蒿素体内青蒿酸的生物合成

黄敬坚;周风仪;吴莲芬;曾桂辉   

  1. 中国科学院上海有机化学研究所
  • 发布日期:1990-03-15

Studies on the biosynthesis of arteannuin I. The in vivo biosynthesis of arteannuic acid of artemisia annual

HUANG JINGJIAN;ZHOU FENGYI;WU LIANFEN;ZENG GUIHUI   

  • Published:1990-03-15

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509

应用幼苗水培法或顶株扦插法, 在青蒿植株体内以[2-^1^4c]-3,5-二羟基-3-甲基戊酸-δ-内酯([2-^1^4C]-MVA)为前体, 成功地生物合成了青蒿酸(3).

关键词: 内酯, 戊酸 P, 生物合成, 青蒿素, 青蒿酸

The incorporation of [2-14C]mevalonic acid lactone (I) in the in vivo biosynthesis of arteannuic acid (II) in Artemisia annua was proved by both the plantlet hydroponic and the stem tip cutting methods. The radioactivity yield of II ranged 0.006-0.020%. It is apparent that I is a precursor of II in A. annua.

Key words: LACTONES, VALERIANIC ACID P, BIOSYNTHESIS, ARTEANNUIN, ARTEANNUIC ACID

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