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化学学报
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化学学报 ›› 1995, Vol. 53 ›› Issue (12): 1173-1177. 上一篇    下一篇

研究论文

配体与金属硫蛋白反应动力学和机理研究

岳晟;仲维清;张保林;朱凌燕;唐雯霞   

  1. 南京大学配位化学国家重点实验室
  • 发布日期:1995-12-15

Kinetics and mechanism studies of reaction of metallothionein with some ligands

YUE SHENG;ZHONG WEIQING;ZHANG BAOLIN;ZHU LINGYAN;TANG WENXIA   

  • Published:1995-12-15

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560

被引次数

1

制备了Cd7Th, Zn7Th, Pb7Th, Hg7Th, Bi7Th等一系列金属硫蛋白(Thionein简称Th), 研究了它们与配体反应的动力学, 根据表观假一级反应速率常数, 提出了不同配体与金属硫蛋白反应的两种机理, 并且讨论了金属硫蛋白被Cd^2^+,Pb^2^+, Hg^2^+等重金属离子在体内诱导的不同形成行为。

关键词: 紫外分光光度法, 锌, 反应机理, 反应动力学, 汞, 镉, 铅, 铋, 配体, EDTA

Cd7Th, Zn7Th, Bi7Th, Hg7Th and Pb7Th have been prepared, and the kinetics of reactions of these five MTs with varied ligands were discussed. From the observed pseudo-first order rate constants, two possible mechanism were determined respectively. The reason of induction behaviors of varied heavy metal ions in vivo also was suggested on the basis of above results.

Key words: ULTRAVIOLET SPECTROPHOTOMETRY, ZINC, REACTION MECHANISM, REACTION KINETICS, MERCURY, CADMIUM, LEAD, BISMUTH, LIGANDS, METALLOTHIONEIN

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