关键词: 氨基酸, 分子烙印, 高聚物, 固定相, 消旋体拆分, 功能性高聚物, 丙烯酰胺, 吡啶P

The effect of functional monomer on chiral separation ability of the non-covalent molecular imprinted chiral stationary phase was investigated systematically. It was found that there was compatibleness between the functional monomer and the template molecules. Strong hydrogen bond and ionic interaction could be formed betweent he amide group and carboxyl group in the amino acid derivatives and acrylamide and 2-vinylpyridine, which made the imprinting effect of the combined functional monomers AM+2-VP more evident. The competing solvent acetic acid showed great influence on the non-covalent interaction between the analyte and the functional groups of molecular imprinted polymer (MIP). Ionic interaction and hydrogen bonding between amide group and carboxyl group in the analyte and the functional groups of MIP were weakened by increasing the concentration of the competing solvent acetic acid, therefore both the capacity factor, chiral selectivity factor and resolution decreased.

Key words: AMINO ACID, HIGHPOLYMER, STATIONARY PHASE, MESOTOMY, FUNCTIONAL POLYMER, PROPENAMIDE, PYRIDINE P