化学学报 ›› 2001, Vol. 59 ›› Issue (6): 803-814.    下一篇

研究论文

质谱在生命有机磷化学中的一些应用

付华;陈益;赵玉芬   

  1. 清华大学生命科学与工程研究院;化学系生命有机磷化学教育部重点实验室
  • 发布日期:2001-06-15

The applications of mass spectrometry in bioorganic phosphorus chemistry

Fu Hua;Chen Yi;Zhao Yufen   

  • Published:2001-06-15

讨论了质谱在生命有机磷化学中的应用,包括N-磷酰氨基酸、肽、五配位磷化合物、核苷-氨基酸磷酰胺的质谱裂解途径,有机磷试剂辅助下氨基酸的自组装成肽产物和机理。

关键词: 质谱法, 磷酰氨基酸, 核苷, 磷酸酯, 肽, 磷酰化合物, 有机磷化合物, 反应机理

Mass spectrometry plays important roles in bioorganic chemistry for its fast determination, high sensitivity and direct analysis of mixtrure. In this paper, some applications of mass spectrometry in bioorganic phosphorus chemistry are discussed including mass spectral fragmentation pathways of N-phosphoamino acids, peptides, pentacoordinatedphosphorus compounds, amino acid phosphoramidates of nucleosides, the selfassembly products and the mechanism of amino acids into peptides mediated by organic phosphorus reagents.

Key words: MASS SPECTROGRAPHY, NUCLEOSIDE, PHOSPHATES, PEPTIDE, PHOSPHORYL COMPOUNDS, ORGANO PHOSPHORUS COMPOUNDS, REACTION MECHANISM

中图分类号: