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化学学报
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化学学报 ›› 2002, Vol. 60 ›› Issue (10): 1883-1886. 上一篇    下一篇

研究论文

一步法合成2-芳基咪唑并[2，1-a]异喹啉等杂环化合物

王炳祥;孙缓缓;李国栋;王晓蓉;胡宏纹   

  1. 南京大学.南京(210093);南京大学化学与化工学院,南京(210093)
  • 发布日期:2002-10-15

A Novel Method for the Synthesis of 2-Arylimidazo(2,1-a) isoquinolines

Wang Bingxiang;Sun Yuanyuan;Li Guodong;Wang Xiaorong;Hu Hongwen   

  1. State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University,Nanjing(210093)
  • Published:2002-10-15

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由异喹啉、喹啉或酞腈与α-卤代苯乙酮反应生成的鎓盐在二氢铬酸四吡啶合? 埽═PCD）存在下与乙酸铵反应，可一步法合成咪唑并[2,1-a]异喹啉(2a～2b)、? 溥虿1,2-a]喹啉(4a～4b)或咪唑并[1,2-a]酞腈(6a～6c)衍生物，该方法原料易? 茫从μ跫子诳刂疲佣峁┝艘恢趾铣烧饫嗷衔锏男路椒ā?

关键词: 咪唑 P, 喹啉 P, 苯乙酮 P乙酸胺 P, 异喹啉, 吡啶 P

A one-pot procedure has been developed to prepare the derivatives of 2-arylimidazo (2,1-a)-isoquinolines (2a～2b), 2-arylimidazo (1,2-a) quinolines (4a～4b) and 2-arylimidazo (1,2-a) phthalazines (6a～6c) in moderate yields (51%～62%) by the reaction of isoquinolinium salts, quinolinium salts or phthalazinium salts with ammonium acetate in the presence of tetrakispyridine cobalt(II) dichromate (TPCD).

Key words: GLYOXALINE P, QUINOLINE P, ACETOPHENONE P, ACETAMIDE P, ISOQUINOLINE, PYRIDINE P

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