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化学学报
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化学学报 ›› 2002, Vol. 60 ›› Issue (2): 338-342. 上一篇    下一篇

研究论文

β-三芳基锗-α(β)-取代丙酸同1-乙氧基锡杂恶唑烷的 反应

宋雪清;罗宁;孙丽娟;谢庆兰   

  1. 南开大学元素有机化学国家重点实验室.天津(300071);重庆市经济委员会安全 生产局
  • 发布日期:2002-02-15

The reaction of β-trialkylgermanium-α(β)-substituted propionic acid with 1-ethoxystannatrane

Song Xueqing;Luo Ning;Sun Lijuan;Xie Qinglan   

  1. Nankai Univ., Dept of prevent med.Tianjin(300071)
  • Published:2002-02-15

PDF

469

被引次数

9

利用β-三芳基锗-α(β)-取代丙酸同1-乙氧基锡杂恶唑烷的1-位取代反应，合成了15个1-[(β-三芳基锡-α(β)-丙酰氧基]-2,8,9-三氧杂-5-氮杂-1-锡杂三环[3,3,3,0^1.5]十一烷，并研究该反应规律，利用IR，NMR和MS表征了该类化合物的结构和质谱裂解机制，生物活性测定表明，它们只对某些细菌如溶血链球菌和金黄葡萄糖球菌有较好的抑制作用。

关键词: 笼状结构, 有机金属化合物, 生物活性, 杀菌剂, 结构表征, 恶唑烷P, 有机锡化合物, 有机锗化合物

The reaction of β-trialkylgermanium-α(β)-substituted propionic acid with 1-ethoxystannatrane was studied and fifteen organometallic compounds containing germanium and tin were synthesized. The procedure of this reaction was described. The structures of prepared compounds were characterized by means of IR, NMR(^1H, ^119Sn) and MS. The fragmentation mechanism of MS was proposed. The tests of biological activity showed that they have better inhibition activity only for some bacteria such as Beta hemolytic strepto coai and Staphylococus aureus.

Key words: CAGE STRUCTURE, ORGANOMETALLIC COMPOUNDS, BIOLOGICAL ACTIVITY, BACTERICIDAL AGENTS, STRUCTURE CHARACTERISTICS, ORGANO TIN COMPOUNDS, ORGANO GERMANIUM

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