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化学学报
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化学学报 ›› 2002, Vol. 60 ›› Issue (9): 1694-1699. 上一篇    下一篇

研究论文

氨基酸钛螯合物和高分子氨基酸钛螯合物对N-丙烯酰-1，3-噁唑烷-2-酮与环? 於┑腄iels-Alder反应的对映选择性催化作用

阳年发;杨利文;邓培红;周元清;张劲   

  1. 湘潭大学化学学院,湘潭(411105)
  • 发布日期:2002-09-15

Enantioselective Catalysis of Free and Polymer-Supported Complexes of Titanium with Sulfonylamino Acids for the Diels-Alder Reaction of N- Propenoyl-1,3-oxazolidin-2-one with Cyclopentadiene

Yang Nianfa;Yang Liwen;Deng Peihong;Zhou Yuanqing;Zhang Jin   

  1. College of Chemistry, Xiangtan University,Xiangtan(411105)
  • Published:2002-09-15

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用磺酰化的L-缬氨酸、L-苯丙氨酸、L-亮氨酸和L-异亮氨酸的钛螯合物催化N- 丙烯酰-1，3-噁唑烷-2-酮与环戊二烯的对映选择性Diels-Alder（D-A）反应，其 ee值为48.1% ～ 78.2%。将这些磺酰基氨基酸钛螯合物受载于高分子链上，用来催 化同一D-A反应时，反应的对映选择性更好，其ee值为82.8% ～ 84.5%。

关键词: 氨基酸, 恶唑烷酮 P, 环戊二烯, 缬氨酸, 苯丙氨酸, 亮氨酸

The enantioselective Diels-Alder reaction of N-propenoyl-1,3- oxazolidin-2-one with cyclopentadiene was catalyzed by free and polymer- supported complexes of titanium with N-sulfonyl-L-amino acids. The L- amino acids used in this study were valine, phenylalanine, leucine and isoleucine. The ee values of the reactions catalyzed by the free and polymer-supported complexes were 48.1% ～ 78.2% and 82.8% ～ 84.5%, respectively.

Key words: AMINO ACID, OXAZOLIDINONE P, CYCLOPENTADIENE, VALINE, PHENYLALANINE, LEUCINE

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