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化学学报
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化学学报 ›› 2003, Vol. 61 ›› Issue (9): 1516-1520. 上一篇    

研究论文

二丁基氧化锡在糖苷类化合物脱乙酰保护基中的应用

李雯;刘宏民;尤启冬   

  1. 中国药科大学药学院;郑州大学化学系
  • 发布日期:2003-09-15

Application of Dibutyltin Oxide to Deacetylation of Glucosides

Li Wen;Liu Hongmin;You Qidong   

  1. School of Pharmaceutic, China Pharmaceutical University;Department of Chemistry, Zhengzhou University
  • Published:2003-09-15

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1411

被引次数

5

发展了在中性条件下选择性脱乙酰保护基的新方法。该方法以催化剂量的二丁 基氧化锡作催化剂，用甲醇作溶剂，对糖苷类化合物脱乙酰保护基进行了研究。文 中对该反应结果、应用范围与反应机理进行了讨论，本研究表明糖苷类化合物采用 该方法可以顺利得到脱乙酰保护基产物，所得到产物的结构经~1H NMR，IR，元素 分析证实。脱保护基的反应在有机合成中具有很重要的意义，该方法属于首次将二 丁基氧化锡用于脱乙酰保护基的反应中。

关键词: 有机锡化合物, 糖苷, 质子磁共振谱法, 红外分光光度法, 元素分析, 反应机理

A mild selective method for deacetylation has been developed. It' s application to deacetylation of glucosides was studied using catalytic amount of dibutyltin oxide as catalyst and methanol as solvent. The scope and mechanism of the deprotection reaction have been discussed. The present results showed that the method is suitable for deactylation of glycosides. Structures of the products were identified by 'H NMR, IR and elemental analysis. Deacetylation reaction is quite important in organic synthesis. It is the first report to use dibutyltin oxide as catalytic agent in deprotection reaction.

Key words: ORGANO TIN COMPOUNDS, GLYCOSIDE, 1HNMR, IR, ELEMENTAL ANALYSIS, REACTION MECHANISM

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